Acquiring and maintaining a normal oral microbiome: current perspective

Frontiers in Cellular and Infection Microbiology

卷:4

Elena A Nicu¹  Egija eZaura¹  Bastiaan P Krom¹  Bart JF Keijser³ 

[1] Academic Centre for Dentistry Amsterdam;

[2] TNO Earth, Environmental and Life Sciences;

[3] Top Institute Food and Nutrition;

关键词: Placenta;    tolerance;    stability;    mucosal immunity;    colonization resistance;    oral microbiome;   

DOI  :  10.3389/fcimb.2014.00085

来源: DOAJ

【 摘 要 】

The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis – a microbial shift towards a disease, e.g., periodontitis or caries. Although processes that underlie oral diseases have been studied extensively, processes involved in maintaining of a normal, healthy microbiome are poorly understood. In this review we present our hypothesis on how a healthy oral microbiome is acquired and maintained. We introduce our view on the prenatal development of tolerance for the normal oral microbiome: we propose that development of fetal tolerance towards the microbiome of the mother during pregnancy is the major factor for a successful acquisition of a normal microbiome. We describe the processes that influence the establishment of such microbiome, followed by our perspective on the process of sustaining a healthy oral microbiome. We divide microbiome-maintenance factors into host-derived and microbe-derived, while focusing on the host. Finally, we highlight the need and directions for future research.

【 授权许可】

Unknown