Non-alcoholic fatty liver disease and obesity among adult donors are major challenges to living-donor liver transplantation: A single-center experience

Asian Journal of Surgery

卷:45

Boon-Koon Yoong¹  Sanjiv Mahadeva²  Jun-Kit Koong²  Fadhil H. Jamaluddin²  Ruveena B. Rajaram³  Pui San Loh⁴  Peng-Soon Koh⁴  Alizan A. Khalil⁴  Noorjahan Haneem Md Hashim⁴  Thevaraajan Jayaraman⁵ 

[1] Corresponding author.Faculty of Medicine, Universiti Teknologi MARA, 47000 Jalan Hospital, Sungai Buloh, Selangor, Malaysia.;

[2] Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

[3] Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia;

[4] Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

[5] Gastroenterology Unit, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia;

关键词: Liver transplantation;    Live donor;    Metabolic syndrome;    Hepatic steatosis;    Evaluation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: Obesity and non-alcoholic fatty liver disease (NAFLD) are rampant in South East Asia. There is paucity of data exploring its’ impact on donor suitability for living donor liver transplantation (LDLT). We aimed to describe and examine the factors related to non-utilization of potential donors in our LDLT programme. Methods: This is an analysis of prospectively collected data on potential donors for an adult LDLT programme, between January 2017 and December 2019. Results: Fifty-five donors for 33 potential recipients were evaluated. The mean age was 31.6 ± 8.5 years, 52.7% were female and the ethnic divisions were: Chinese (50.9%), Indian (25.5%) and Malay (23.6%). The mean body mass index (BMI) among potential donors was 25.1 ± 4.0 kg/m2; 25.5% of donors had normal BMI, 23.6% were overweight and 50.9% were obese. Using the CAP modality of Fibroscan®, we identified the following grades of hepatic steatosis: 36.6% S0, 19.5% S1, 2.4% S2 and 41.5% S3. The non-utilization rate of our donors was 74.5% (41/55) and the main reasons were significant hepatic steatosis and/or obesity. Compared to suitable donors, unsuitable donors had significantly greater mean BMI, mean CAP scores, higher rates of dyslipidaemia and NAFLD. Conclusion: NAFLD and obesity represent major challenges to an emerging LDLT programme in Malaysia.

【 授权许可】

Unknown