Antigen-Presenting Cells in Food Tolerance and Allergy

Frontiers in Immunology

卷:11

Stephanie C. Eisenbarth²  Anush Swaminathan²  Xiangyun Yin³  Elise G. Liu⁴ 

[1] Immunology, Yale University School of Medicine, New Haven, CT, United States;

[2] Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States;

[3] Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, United States;

[4] Section of Rheumatology, Allergy &

关键词: food allergy;    dendritic cells;    oral tolerance;    monocytes;    gut;    mesenteric lymph node;   

DOI  :  10.3389/fimmu.2020.616020

来源: DOAJ

【 摘 要 】

Food allergy now affects 6%–8% of children in the Western world; despite this, we understand little about why certain people become sensitized to food allergens. The dominant form of food allergy is mediated by food-specific immunoglobulin E (IgE) antibodies, which can cause a variety of symptoms, including life-threatening anaphylaxis. A central step in this immune response to food antigens that differentiates tolerance from allergy is the initial priming of T cells by antigen-presenting cells (APCs), primarily different types of dendritic cells (DCs). DCs, along with monocyte and macrophage populations, dictate oral tolerance versus allergy by shaping the T cell and subsequent B cell antibody response. A growing body of literature has shed light on the conditions under which antigen presentation occurs and how different types of T cell responses are induced by different APCs. We will review APC subsets in the gut and discuss mechanisms of APC-induced oral tolerance versus allergy to food identified using mouse models and patient samples.

【 授权许可】

Unknown