Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats

Biomedicine & Pharmacotherapy

卷:121

Yi Hu¹  Wenjing Feng²  Luyan Yu²  Pengli Li²  Huashi Guan³  Yongjun Mao³  Bing Cai⁴  Chunxia Li⁴ 

[1] Department of Geriatric Medicine, The affiliated hospital of Qingdao University, Qingdao 266003, China;

[2] Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;

[3] Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China;

关键词: PSS-loaded nanoparticles;    Microcirculation dysfunction;    Diabetic cardiomyopathy;    Vascular endothelial function;    Coagulation;    Oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

Coronary microvascular dysfunction (CMD) is the pathological basis and pathogenesis of diabetic cardiomyopathy (DCM). Propylene glycol alginate sodium sulfate (PSS) as heparinoid drug has many biological activities. Here, a novel PSS-loaded nanoparticle (PSS-NP) was prepared to study its effect on the CMD of DCM. We used diabetes mellitus rat induced by STZ to establish the CMD model of DCM, and the study was detected by echocardiography, histological analysis, transmission electron microscopy, immunofluorescence staining, enzyme-linked immunosorbent assay, real time-PCR analysis, liquid-chip analysis, western blot analysis and so on. The experimental results suggested that PSS-NP could improve the survival state of rats, cardiac function, myocardial morphology and coronary microcirculation structure disorders, and increase the number of microvessels. In addition, we demonstrated that PSS-NP could alleviate the CMD by improving endothelial function, anticoagulation and antioxidative stress. The outcomes of this study provided new treatment thoughts for the therapy of coronary microcirculation dysfunction in DCM.

【 授权许可】

Unknown