Sex-specific cardiovascular responses to control or high fat diet feeding in C57bl/6 mice chronically exposed to bisphenol A.

Toxicology Reports

卷:2

Igal A. Sebag¹  Bhavini B. Patel²  Lorraine E. Chalifour²  Mohamad Raad² 

[1] Division of Cardiology, Jewish General Hospital, 3755 chemin Cote Ste Catherine, Montreal, Quebec H3T 1E2, Canada;

[2] Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 chemin Cote Ste Catherine, Montreal, Quebec H3T 1E2, Canada;

关键词: Bisphenol A;    Diethylstilbestrol;    High fat diet;    Electrocardiograph;    Echocardiograph;    Calcium homeostasis;   

DOI  :  10.1016/j.toxrep.2015.09.008

来源: DOAJ

【 摘 要 】

The increased pericardial fat which often accompanies overall obesity is thought to alter cardiac structure/function and increase the risk for atrial fibrillation. We hypothesized that chronic exposure to bisphenol A (BPA) would induce pericardial fat, cardiac hypertrophy or arrhythmia. C57bl/6n dams were exposed to BPA (25 ng/ml drinking water) beginning on gestation day 11 and progeny continued on 2.5 ng BPA/ml drinking water. The progeny of control dams (VEH) and dams treated with diethylstilbestrol (DES, 1 μg/kg/day, gestation days 11–14) had tap water. After weaning progeny were fed either a control (CD) or high fat diet (HFD) for 3 months. Pericardial fat was present in CD-BPA and CD-DES and not CD-VEH mice, and was increased in all HFD mice. Catecholamine challenge revealed no differences in males, but BPA-exposed females had longer P-wave and QRS complex duration. Only CD-BPA and CD-DES females developed cardiac hypertrophy which was independent of increased blood pressure. Calcium homeostasis protein expression changes in HFD-BPA and HFD-DES mice predict reduced SERCA2 activity in males and increased SERCA2 activity in females. Thus, chronic BPA exposure induced pericardial fat in the absence of HFD, and female-specific changes in cardiac hypertrophy development and cardiac electrical conduction after a catecholamine challenge.

【 授权许可】

Unknown