Phylogenetic analysis of the human receptor of SARS-CoV-2 coronavirus and its implications for the biology of infection

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta

卷:45

Orlando Rafael Serrano-Barrera¹ 

[1] Hospital General Docente “Dr. Ernesto Guevara de la Serna”, Las Tunas.Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.;

关键词: phylogeny;    sars virus;    pandemics;    computational biology;    disease reservoirs;    sars-cov-2;    covid-19;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: angiotensin converting enzyme 2 (ACE2) is the receptor used by SARS-CoV-2 to infect human cells and produce infection in humans.

Objective: to compare the sequence of the receptor with those of other animal species, in order to extract useful information to better understand and fight the current pandemics.

Methods: from a sequence of human ACE2, obtained from UniProtKB, multiple alignments were done with homolog proteins from bats, non-human primates and other vertebrates. CLUSTAL O tool was used, and phylogenetic trees were obtained from UniProt and Ensembl.

Results: full phylogenetic conservation of ACE2 residues was found in relation to the recognition of its natural ligands and substrates, in all the species studied. Only among non-human primates there was absolute similarity in the aminoacids that interact with S glycoprotein from SARS-CoV-2: Q24, D30, H34, Y41, Q42, M82, N90, K353 and R357.

Conclusions: several primates could serve as hosts for the new coronavirus. New elements are given for the comprehension of the emergence of the new coronavirus as a human pathogen.

【 授权许可】

Unknown