Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report

International Journal of Molecular Sciences

卷:22

Jan Maciej Zaucha¹  Tomasz Smiatacz²  Jacek Jassem³  Ewa Jassem⁴  Ines Papak⁵  Łukasz Arcimowicz⁵  Natalia Maria Marek-Trzonkowska⁵ 

[1] Department of Haematology, Medical University of Gdańsk;

[2] Department of Infectious Diseases, Medical University of Gdańsk, 80-214 Gdańsk, Poland;

[3] Department of Oncology and Radiotherapy, Medical University of Gdańsk, 80-214 Gdańsk, Poland;

[4] Department of Pneumonology, Medical University of Gdańsk, 80-214 Gdańsk, Poland;

[5] International Centre for Cancer Vaccine Science, University of Gdańsk, 80-822 Gdańsk, Poland;

关键词: COVID-19;    oligoclonal T cell response;    TCR Vβ repertoire;    CD8+ cytotoxic T cells;    natural killer cells (NK cells);   

DOI  :  10.3390/ijms222010934

来源: DOAJ

【 摘 要 】

We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectively respond to anti-SARS-CoV-2 treatment when NK and antigen-specific Tc cell response is induced.

【 授权许可】

Unknown