Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia in a patient with multiple pulmonary nodules: case report and literature review

Southwest Journal of Pulmonary and Critical Care

卷:15

Hawarri F¹  Labib M¹  Haddad H¹  Massad E¹  Yamin HS¹ 

[1] King Hussein Cancer Center, Amman, Jordan;

关键词: DIPNECH;    carcinoid tumorlets;    asthma;    bronchiolitis;    obstructive lung disease;    demography;    CT scan;    histology;    therapy;    corticosteroids;   

DOI  :  10.13175/swjpcc139-17

来源: DOAJ

【 摘 要 】

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary disease, where carcinoid tumorlets invade the pulmonary parenchyma and bronchioles. These nests of cells release a variety of mediators including bombesin and gastrin releasing peptide that cause heterogeneous bronchoconstriction, creating a mosaic appearance on chest imaging studies, especially on expiratory scans. Clinically patients usually have long standing symptoms of shortness of breath (SOB) and cough that are difficult to distinguish from asthma. In this article we describe a case of DIPNECH in a patient with several years’ history of SOB and cough, and review 179 cases of DIPNECH reported in the literature since 1992.

【 授权许可】

Unknown