Neurochemical Changes in the Brain and Neuropsychiatric Symptoms in Clinically Isolated Syndrome

Journal of Clinical Medicine

卷:9

Wojciech Guenter¹  Alina Borkowska¹  Maciej Bieliński¹  Robert Bonek² 

[1] Department of Clinical Neuropsychology, Nicolaus Copernicus University, 87-100 Toruń, Poland, and Collegium Medicum, 85-094 Bydgoszcz, Poland;

[2] Regional Specialized Hospital in Grudziądz, Division of Neurology and Clinical Neuroimmunology, 86-300 Grudziądz, Poland;

关键词: clinically isolated syndrome;    multiple sclerosis;    cognition;    neuropsychology;    proton magnetic resonance spectroscopy;   

DOI  :  10.3390/jcm9123909

来源: DOAJ

【 摘 要 】

To assess cognitive impairment and affective symptoms and their association with damage to normal-appearing white matter (NAWM) in patients with clinically isolated syndrome (CIS), we compared neuropsychological test scores between patients with CIS and healthy controls and examined correlations between these and proton magnetic resonance spectroscopy (¹H-MRS) outcomes in patients with CIS. Forty patients with CIS and 40 healthy participants were tested with a set of neuropsychological tests, which included the Beck Depression Inventory (BDI) and the Hospital Anxiety and Depression Scale (HADS). Single-voxel ¹H-MRS was performed on frontal and parietal NAWM of patients with CIS to assess ratios of N-acetyl-aspartate (NAA) to creatine (Cr), myo-inositol (mI), and choline (Cho), as well as mI/Cr and Cho/Cr ratios. Patients with CIS had lower cognitive performance and higher scores for the BDI and anxiety subscale of HADS than healthy controls. There were significant correlations between the following neuropsychological tests and metabolic ratios in the frontal NAWM: Stroop Color-Word Test and Cho/Cr, Symbol Digit Modalities Test and mI/Cr, as well as NAA/mI, Go/no-go reaction time, and NAA/Cho, as well as NAA/mI, Californian Verbal Learning Test, and NAA/Cr. BDI scores were related to frontal NAA/mI and parietal NAA/Cr and Cho/Cr ratios, whereas HADS-depression scores were associated with frontal NAA/Cr and NAA/mI and parietal NAA/Cr and Cho/Cr ratios. HADS-anxiety correlated with parietal NAA/Cr ratio. This study suggests that neurochemical changes in the NAWM assessed with single-voxel ¹H-MRS are associated with cognitive performance and affective symptoms in patients with CIS.

【 授权许可】

Unknown