Current Perspectives on Clinical Use of Exosomes as a Personalized Contrast Media and Theranostics

Cancers

卷:12

Julian Chrzanowski¹  Wioletta Olejarz¹  Tomasz Lorenc² 

[1] Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland;

[2] Ist Department of Clinical Radiology, Medical University of Warsaw, 5 Chalubinskiego Street, 02-004 Warsaw, Poland;

关键词: cancer;    diagnostic imaging;    contrast media;    personalized radiology;    theranostics;    exosomes;   

DOI  :  10.3390/cancers12113386

来源: DOAJ

【 摘 要 】

An appropriate combination of biomarkers and imaging technologies will become standard practice in the future. Because the incidence of and mortality from cancers is rising, the further study of new approaches for the early detection and precise characterization of tumors is essential. Extracellular vesicles (EVs), including exosomes, prove to have great potential when it comes to diagnosis and targeted therapy. Due to their natural ability to pass through biological barriers, depending on their origin, EVs can accumulate at defined sites, including tumors, preferentially. This manuscript discusses the difficulties and simplicities of processing cell-derived materials, packaging diverse groups of agents in EVs, and activating the biological complex. Developing exosome-based diagnostic techniques to detect disease precisely and early as well as treat disease marks a new era of personalized radiology and nuclear medicine. As circulating drug delivery vehicles for novel therapeutic modalities, EVs offer a new platform for cancer theranostic.

【 授权许可】

Unknown