Pathophysiology of Fibrosis in the Vocal Fold: Current Research, Future Treatment Strategies, and Obstacles to Restoring Vocal Fold Pliability

International Journal of Molecular Sciences

卷:20

Yoshihiko Kumai¹ 

[1] Department of Otolaryngology Head and Neck Surgery, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan;

关键词: vocal fold;    scar;    tissue engineering;    adipose-derived stem cell;    bone marrow derived stem cell;    anti-fibrotic agents;    pliability;    anti-inflammatory cytokine;    exosome;    gene therapy;    laser therapy;   

DOI  :  10.3390/ijms20102551

来源: DOAJ

【 摘 要 】

Communication by voice depends on symmetrical vibrations within the vocal folds (VFs) and is indispensable for various occupations. VF scarring is one of the main reasons for permanent dysphonia and results from injury to the unique layered structure of the VFs. The increased collagen and decreased hyaluronic acid within VF scars lead to a loss of pliability of the VFs and significantly decreases their capacity to vibrate. As there is currently no definitive treatment for VF scarring, regenerative medicine and tissue engineering have become increasingly important research areas within otolaryngology. Several recent reviews have described the problem of VF scarring and various possible solutions, including tissue engineered cells and tissues, biomaterial implants, stem cells, growth factors, anti-inflammatory cytokines antifibrotic agents. Despite considerable research progress, these technical advances have not been established as routine clinical procedures. This review focuses on emerging techniques for restoring VF pliability using various approaches. We discuss our studies on interactions among adipose-derived stem/stromal cells, antifibrotic agents, and VF fibroblasts using an in vitro model. We also identify some obstacles to advances in research.

【 授权许可】

Unknown