In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo

Journal of Extracellular Vesicles

卷:11

Yvonne Couch¹  Ryan C. Pink²  Paschalia Pantazi²  Elizabeth R. Dellar²  Uta Erdbrügger³  Daniel C. Anthony⁴  Abi G. Yates⁴  Naveed Akbar⁵  Emmanuel Dias‐Neto⁶  Pia R‐M. Siljander⁷  William R. Cooke⁸  Manu Vatish⁸ 

[1] Acute Stroke Programme ‐ Radcliffe Department of Medicine University of Oxford John Radcliffe Hospital, Headington Oxford UK;

[2] Department of Biological and Medical Sciences Faculty of Health and Life Sciences Oxford Brookes University Headington Campus Oxford UK;

[3] Department of Medicine, Division of Nephrology University of Virginia Charlottesville Virginia USA;

[4] Department of Pharmacology University of Oxford Oxford UK;

[5] Division of Cardiovascular Medicine, Radcliffe Department of Medicine University of Oxford Oxford UK;

[6] Laboratory of Medical Genomics. A.C. Camargo Cancer Centre São Paulo Brazil;

[7] Molecular and Integrative Biosciences Research Programme Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland;

[8] Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK;

关键词: exosomes;    extracellular vesicles;    in vivo;    microvesicles;    pathology;    physiology;   

DOI  :  10.1002/jev2.12151

来源: DOAJ

【 摘 要 】

Abstract Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are now known to mediate physiological and pathological functions throughout the body. We now understand more about their capacity to transfer nucleic acids and proteins between distant organs, the interaction of their surface proteins with target cells, and the role of vesicle‐bound lipids in health and disease. To date, most observations have been made in reductionist cell culture systems, or as snapshots from patient cohorts. The heterogenous population of vesicles produced in vivo likely act in concert to mediate both beneficial and detrimental effects. EVs play crucial roles in both the pathogenesis of diseases, from cancer to neurodegenerative disease, as well as in the maintenance of system and organ homeostasis. This two‐part review draws on the expertise of researchers working in the field of EV biology and aims to cover the functional role of EVs in physiology and pathology. Part I will outline the role of EVs in normal physiology.

【 授权许可】

Unknown