Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

Microorganisms

卷:9

Eva Salinas¹  Diana Reyes-Pavón¹  Oscar K. Bitzer-Quintero²  Luis G. Bermúdez-Humarán³  Edgar Torres-Maravilla³  Philippe Langella³  Naima G. Cortes-Perez⁴ 

[1] Department of Microbiology, Basic Science Center, Autonomous University of Aguascalientes, Aguascalientes 20100, Mexico;

[2] Neurosciences Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico;

[3] Université Paris-Saclay, AgroParisTech, Micalis Institute, INRAE, 78350 Jouy-en-Josas, France;

[4] Université Paris-Saclay, INRAE, AgroParisTech, UMR 0496, 78350 Jouy-en-Josas, France;

关键词: functional food;    probiotics;    prebiotics;    synbiotics;    IBD;    IBS;   

DOI  :  10.3390/microorganisms9081634

来源: DOAJ

【 摘 要 】

The intestinal epithelium serves as an effective barrier against the external environment, hampering the passage of potentially harmful substances (such as pathogenic microbes) that could trigger an exacerbated host immune response. The integrity of this barrier is thus essential for the maintenance of proper intestinal homeostasis and efficient protective reactions against chemical and microbial challenges. The principal consequence of intestinal barrier defects is an increase in intestinal permeability, which leads to an increased influx of luminal stressors, such as pathogens, toxins, and allergens, which in turn trigger inflammation and immune response. The fine and fragile balance of intestinal homeostasis can be altered by multiple factors that regulate barrier function, many of which are poorly understood. This review will address the role of gut microbiota as well as food supplements (such as probiotics, prebiotics, and synbiotics) in modulating gut health and regulating intestinal barrier function. In particular, we will focus on three human pathologies: inflammatory bowel disease, irritable bowel syndrome, and food allergy.

【 授权许可】

Unknown