Comparison of Corneal Biomechanics in Post-SMILE, Post-LASEK, and Keratoconic Eyes

Frontiers in Medicine

卷:8

Vishal Jhanji¹  Yu Zhao⁵  Jing Zhao⁵  Xueyi Zhou⁵  Jianmin Shang⁵  Xingtao Zhou⁵  Yang Shen⁵ 

[1] Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States;

[2] Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China;

[3] Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China;

[4] NHC Key Laboratory of Myopia, Fudan University, Shanghai, China;

[5] Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China;

关键词: keratoconus;    SP-A1;    LASEK;    corneal biomechanics;    small incision lenticule extraction;   

DOI  :  10.3389/fmed.2021.695697

来源: DOAJ

【 摘 要 】

Significance: Our study found that SP-A1 (stiffness parameter at time of first applanation) was statistically different between post-laser-assisted subepithelial keratomileusis (LASEK) and post-small incision lenticule extraction (SMILE) eyes. The stiffness of keratoconus was lower than that of post-refractive surgery corneas.Purpose: To compare corneal biomechanics among post-SMILE, post-LASEK, and keratoconic eyes.Methods: In this retrospective study, 36 eyes of 36 patients after SMILE, 36 eyes of 36 patients after LASEK, and 36 eyes of 36 patients with keratoconus with matching (±5 μm) central corneal thickness (CCT) were examined using Scheimpflug corneal topography (Pentacam HR) and dynamic Scheimpflug analyzer (CorVis ST). Mixed linear model analysis with Bonferroni-adjusted post-hoc comparisons was performed to compare the differences in corneal biomechanics and topographic parameters among the three groups with the CCT and the bIOP (intraocular pressure with biomechanical correction) as the random factor.Results: All groups had comparable CCT at baseline. The bIOPs between the three groups were comparable. The mean values of the Belin/Ambrósio Deviation (BAD-D) in the keratoconus group were significantly higher than those of the SMILE (post hoc p < 0.001) and LASEK groups (post hoc p < 0.001). The SP-A1 in the keratoconus group was the lowest when compared with those of the SMILE (post hoc p = 0.003) and LASEK groups (post hoc p < 0.001). The SMILE group SP-A1 values were slightly lower than those of the LASEK group (post hoc p = 0.044).Conclusions: Keratoconus eyes were significantly softer when compared to post-refractive surgery corneas with comparable corneal thickness in terms of SP-A1 and BAD-D values, while the LASEK group may have the greatest stiffness. Post-SMILE and post-LASEK corneas showed significant differences in SP-A1.

【 授权许可】

Unknown