Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

Beilstein Journal of Organic Chemistry

卷:10

Christine Wiebe¹  Marcel Heinz¹  Dorota Ferenc²  Murat Kucukdisli²  Till Opatz² 

[1] Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany;

[2] Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10–14, 55128 Mainz, Germany;

关键词: α-aminonitriles;    cyclization;    heterocycles;    microwave-assisted synthesis;    pyrroles;   

DOI  :  10.3762/bjoc.10.44

来源: DOAJ

【 摘 要 】

The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles.

【 授权许可】

Unknown