Treatment of Gastrointestinal Disorders—Plants and Potential Mechanisms of Action of Their Constituents

Molecules

卷:27

Jaroslav Tóth¹  Silvia Bittner Fialová¹  Pavel Mučaji¹  Milan Nagy¹  on behalf of the OEMONOM¹  Szilvia Czigle¹ 

[1] Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovakia;

关键词: heartburn;    dyspepsia;    nausea;    constipation;    diarrhoea;    phytotherapy;   

DOI  :  10.3390/molecules27092881

来源: DOAJ

【 摘 要 】

The worldwide prevalence of gastrointestinal diseases is about 40%, with standard pharmacotherapy being long-lasting and economically challenging. Of the dozens of diseases listed by the Rome IV Foundation criteria, for five of them (heartburn, dyspepsia, nausea and vomiting disorder, constipation, and diarrhoea), treatment with herbals is an official alternative, legislatively supported by the European Medicines Agency (EMA). However, for most plants, the Directive does not require a description of the mechanisms of action, which should be related to the therapeutic effect of the European plant in question. This review article, therefore, summarizes the basic pharmacological knowledge of synthetic drugs used in selected functional gastrointestinal disorders (FGIDs) and correlates them with the constituents of medicinal plants. Therefore, the information presented here is intended as a starting point to support the claim that both empirical folk medicine and current and decades-old treatments with official herbal remedies have a rational basis in modern pharmacology.

【 授权许可】

Unknown