Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Journal of Pharmacological Sciences

卷:127

Takeshi Suzuki¹  Kaoru Sato²  Koki Fujimori²  Yukari Shigemoto-Mogami²  Junpei Takaki²  Yuko Sekino² 

[1]Division of Basic Biological Science, Faculty of Pharmacy, Keio University, 1-5-30 Shiba-koen, Minato-ku, Tokyo 105-8512, Japan

[2]|Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan

关键词: Paroxetine;    L-glutamate;    Inflammation;   

DOI  :  10.1016/j.jphs.2014.09.002

来源: DOAJ

【 摘 要 】

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

【 授权许可】

Unknown