Assessment of a Screening Questionnaire to Identify Exposure to Lead in Pregnant Women

International Journal of Environmental Research and Public Health

卷:17

Claire Sunyach¹  Jeanne Perrin¹  Naima Hamdaoui¹  Marine Freuchet¹  Florence Bretelle¹  Hélène Heckenroth¹  Blandine Courbiere¹  Eléna Coiplet¹  Julien Mancini²  Christel Pissier³ 

[1] Department of Gynecology-Obstetric and Reproductive Medicine, Women-Parents-Children Centre (Pôle Femmes-Parents-Enfants/Hôpital La Conception), 147 Boulevard Baille, 13005 Marseille, France;

[2] Department of Public Health, Aix-Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hop Timone, BIOSTIC, (Biostatistiques et Technologies de L’information et de la Communication), 13005 Marseille, France;

[3] Pharmacokinetics and Toxicology Laboratory (Laboratoire de Pharmacocinétique et Toxicologie), AP-HM, 13005 Marseille, France;

关键词: lead exposure;    pregnancy;    risk factors;    environment;   

DOI  :  10.3390/ijerph17249220

来源: DOAJ

【 摘 要 】

Lead readily crosses the placenta and displays adverse effects on birth outcomes and neurodevelopment. Systematic identification of the risk of exposure during pregnancy is essential but rarely performed, probably due to hospital staff’s workload and their lack of awareness. We aimed to evaluate the relevance of a questionnaire to screen pregnant women for lead exposure. A cross-sectional, multicentre study was carried out on a population of 792 pregnant women from February 2018 to May 2020. A total of 596 women had a blood lead test: 68.5% had blood lead levels below 10 μg/L. The estimated prevalence above 25 µg/L was 4% (95% confidence interval (CI) [2.6–5.9]) and 1.3% had levels above 50 µg/L (95% CI [0.6–2.6]). Multivariate analysis showed that three risk factors significantly increased the probability of blood lead levels above 25 µg/L: the use of traditional cosmetics (adjusted odds ratio [aOR]: 3.90; 95% CI [1.65–9.21]; p = 0.002), degraded old housing (aOR: 2.67; 95% CI [1.19–6.038]; p = 0.018), and (marginally) eating bread more than twice a day (aOR: 2.40; 95% CI [0.96–6.11]; p = 0.060). Our study reveals that a three-question tool can be used to quickly screen for the risk of lead exposure in our population and to trigger lead blood tests and special vigilance during pregnancy follow-up.

【 授权许可】

Unknown