A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Frontiers in Neurology

卷:9

David Zagzag¹  Bruce Raphael²  Deborah Gruber³  Mark Bustoros⁴  Cynthia Liu⁵  Benjamin Liechty⁵  Timothy Shepherd⁶  Dimitris G. Placantonakis⁸ 

[1] Brain Tumor Center, NYU Langone Medical Center, New York, NY, United States;

[2] Department of Medicine, NYU School of Medicine, New York, NY, United States;

[3] Department of Neurology, NYU School of Medicine, New York, NY, United States;

[4] Department of Neurosurgery, NYU School of Medicine, New York, NY, United States;

[5] Department of Pathology, NYU School of Medicine, New York, NY, United States;

[6] Department of Radiology, NYU School of Medicine, New York, NY, United States;

[7] Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY, United States;

[8] Neuroscience Institute, NYU School of Medicine, New York, NY, United States;

[9] Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, United States;

关键词: extranodal marginal zone lymphoma;    central nervous system lymphoma;    dura;    chronic lymphocytic leukemia/small lymphocytic lymphoma;    composite lymphoma;   

DOI  :  10.3389/fneur.2018.00267

来源: DOAJ

【 摘 要 】

BackgroundPrimary extranodal marginal zone lymphoma (MZL) of the dura is a rare neoplastic entity in the central nervous system (CNS).MethodsWe used literature searches to identify previously reported cases of primary dural MZL. We also reviewed clinical, pathologic, and radiographic data of an adult patient with concurrent dural MZL and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).ResultsWe identified 104 cases of dural MZL in the literature. None of them presented concurrently with another type of non-Hodgkin lymphoma. This is the first report of composite lymphoma consisting of dural MZL and CLL/SLL in the bone marrow and lymph nodes.ConclusionPrimary dural MZL is a rare, indolent low-grade CNS lymphoma, with a relatively good prognosis. Its treatment is multidisciplinary and often requires surgical intervention due to brain compression, along with low to moderate doses of radiotherapy and/or systemic chemotherapy.

【 授权许可】

Unknown