Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity

Frontiers in Immunology

卷:9

Gabriel A. Rabinovich¹  Ana M. Berón²  Gustavo G. Nasswetter²  Santiago P. Mendez-Huergo³  Nicolás A. Pinto³  Juan C. Stupirski³  Luciano G. Morosi³  Pablo F. Hockl³  Sebastián M. Maller³  Javier A. Cavallasca⁴  Jorge L. Musuruana⁴ 

[1] Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina;

[2] División Reumatología, Hospital de Clínicas “José de San Martín”, Universidad de Buenos Aires, Buenos Aires, Argentina;

[3] Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;

[4] Sección de Reumatología y Enfermedades Autoinmunes Sistémicas, Hospital “José Bernardo Iturraspe”, Santa Fe, Argentina;

关键词: rheumatoid arthritis;    galectin-1;    galectin-3;    inflammation;    autoimmune disease;   

DOI  :  10.3389/fimmu.2018.03057

来源: DOAJ

【 摘 要 】

Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a chronic multifactorial autoimmune disease characterized by inflammatory responses that affects both articular and extra-articular tissues. Galectins have been reported to play central roles in RA and its experimental animal models. In this perspective article we present new data highlighting the regulated expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in sera from RA patients under disease-modifying anti-rheumatic drugs (DMARDs) and/or corticoid treatment in the context of a more comprehensive discussion that summarizes the roles of galectins in joint inflammation. We found that Gal-1 levels markedly increase in sera from RA patients and positively correlate with erythrocyte sedimentation rate (ERS) and disease activity score 28 (DAS-28) parameters. On the other hand, Gal-3 is downregulated in RA patients, but positively correlates with health assessment questionnaire parameter (HAQ). Finally, by generating receiver-operator characteristic (ROC) curves, we found that Gal-1 and Gal-3 serum levels constitute good parameters to discriminate patients with RA from healthy individuals. Our findings uncover a differential regulation of Gal-1 and Gal-3 which might contribute to the anti-inflammatory effects elicited by DMARDs and corticoid treatment in RA patients.

【 授权许可】

Unknown