Risk assessment and seroprevalence of SARS-CoV-2 infection in healthcare workers of COVID-19 and non-COVID-19 hospitals in Southern Switzerland

The Lancet Regional Health. Europe

卷:1

Sandra Jovic¹  Enos Bernasconi²  Federica Sallusto³  Giovanni Piumatti⁴  Federico Mele⁵  Emiliano Albanese⁶  Stefano Jaconi⁷  Alessandro Ceschi⁸  Paolo Ferrari⁸  Blanca Fernandez Rodriguez⁹  Davide Corti¹⁰  Luca Piccoli¹⁰  Nicole Sprugasci¹⁰  Antonio Lanzavecchia¹⁰  Istvan Bartha¹⁰  Mariagrazia Uguccioni¹⁰  Christian Garzoni¹⁰  Elisabetta Cameroni¹¹  Chiara Silacci-Fregni¹¹  Tatiana Terrot¹¹  Olivier Giannini¹¹  Luigia Elzi¹¹  Isabella Giacchetto-Sasselli¹¹ 

[1] Clinical School, University of New South Wales, Sydney, Australia;

[2] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (Milan), Italy;

[3] Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland;

[4] Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland;

[5] nstitute of Public Health, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland;

[6] Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland;

[7] Clinical Trial Unit, Ente Ospedaliero Cantonale, Lugano, Switzerland;

[8] Department of Internal Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland;

[9] Division of Primary Care, Population Epidemiology Unit, Geneva University Hospitals, Geneva, Switzerland;

[10] Humabs BioMed SA, A Subsidiary of Vir Biotechnology, Bellinzona, Switzerland;

[11] Institute for Research in Biomedicine, Bellinzona, Università della Svizzera italiana, Bellinzona, Switzerland;

关键词: COVID-19;    Healthcare workers;    Seroprevalence;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary:Background: Hospital healthcare workers (HCW), in particular those involved in the clinical care of COVID-19 cases, are presumably exposed to a higher risk of acquiring the disease than the general population. Methods: Between April 16 and 30, 2020 we conducted a prospective, SARS-CoV-2 seroprevalence study in HCWs in Southern Switzerland. Participants were hospital personnel with varying COVID-19 exposure risk depending on job function and working site. They provided personal information (including age, sex, occupation, and medical history) and self-reported COVID-19 symptoms. Odds ratio (OR) of seropositivity to IgG antibodies was estimated by univariate and multivariate logistic regressions. Findings: Among 4726 participants, IgG antibodies to SARS-CoV-2 were detected in 9.6% of the HCWs. Seropositivity was higher among HCWs working on COVID-19 wards (14.1% (11.9–16.5)) compared to other hospital areas at medium (10.7% (7.6–14.6)) or low risk exposure (7.3% (6.4–8.3)). OR for high vs. medium wards risk exposure was 1.42 (0.91–2.22), P = 0.119, and 1.98 (1.55–2.53), P<0.001 for high vs. low wards risk exposure. The same was for true for doctors and nurses (10.1% (9.0–11.3)) compared to other employees at medium (7.1% (4.8–10.0)) or low risk exposure (6.6% (5.0–8.4)). OR for high vs. medium profession risk exposure was 1.37 (0.89–2.11), P = 0.149, and 1.75 (1.28–2.40), P = 0.001 for high vs. low profession risk exposure. Moreover, seropositivity was higher among HCWs who had household exposure to COVID-19 cases compared to those without (18.7% (15.3–22.5) vs. 7.7% (6.9–8.6), OR 2.80 (2.14–3.67), P<0.001). Interpretation: SARS-CoV-2 antibodies are detectable in up to 10% of HCWs from acute care hospitals in a region with high incidence of COVID-19 in the weeks preceding the study. HCWs with exposure to COVID-19 patients have only a slightly higher absolute risk of seropositivity compared to those without, suggesting that the use of PPE and other measures aiming at reducing nosocomial viral transmission are effective. Household contact with known COVID-19 cases represents the highest risk of seropositivity. Funding: Henry Krenter Foundation, Ente Ospedaliero Cantonale and Vir Biotechnology.

【 授权许可】

Unknown