Chemical characteristics and targeted encapsulated Cordia myxa fruits extracts nanoparticles for antioxidant and cytotoxicity potentials

Saudi Journal of Biological Sciences

卷:28

Khaled F. Mahmoud¹  Mohamed A. Abdelgawad²  Amr Farouk³  Khaled F. El-Massry⁴  Sherif S. M⁴  Ehab M. Mostafa⁵  Mohammed M. Ghoneim⁵  Ibrahim A. Naguib⁶  Ahmed H. El-Ghorab⁷  Arafa Musa⁸ 

[1] Aroma Department, National Research Center, Giza, Egypt;

[2] Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt;

[3] Chemistry of Flavor &

[4] Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia;

[5] Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia;

[6] Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia;

[7] Food Technology Department, National Research Center, Giza, Egypt;

[8] Nutrition and Food Science Department, National Research Center, Giza, Egypt;

关键词: Cordia myxa fruit;    Encapsulation;    Phenolic content;    Flavonoids;    Antioxidant;    Cytotoxicity;   

DOI  :  

来源: DOAJ

【 摘 要 】

A promising Cordia myxa fruit (CMF) extract targets an additional incorporation in functional foods. It retains appropriate health welfares owing to its antioxidant properties with limited incorporation in food matrices due its hydrophobicity. Therefore, CMF extract micro- and nanocapsulation was performed to protect and facilitate consistency of produced hydrophobic foods matrices. Furthermore, to determine its phytochemicals, antioxidant, and cytotoxic effects by applying analytical HPLC, FRAP and SRB assay, respectively. HPLC analysis of the tested extracts revealed the presence of, 25.59 ± 1.78 mg catechin/g, 69.68 ± 4.20 mg quercetin/g, and 112.72 ± 8.38 mg gallic acid/g extract. The CMF extract displayed a potent DPPH radicals' scavenger and FRAP high reduction capability in a dose-dependent manner. The potent pharmacological activities of CMF extract may be ascribed to high concentration of polyphenolics including flavonoids which strongly reported to possess an antitumor and antioxidant activities. To confirm the efficient CMF incorporation in micro- and nanosystems and their thermal stabilities to withstand the high temperatures applied during some food processing. DSC of the apparent melt of non-capsulated CMF and encapsulated forms (MCMF and NCMF) in sodium alginate gel and beads was studied. Results showed that melting point of CMF extract (86.17 °C) indicating its inability whereas the MCMF and NCMF melting points (226.45 and 383.87 °C, respectively) demonstrating the capability of expending alginate – packaging material to shield the vital active compounds of C. myxa fruit to be applied in different targeted delivery products especially that disclosed to high thermal treatments.

【 授权许可】

Unknown