Approach-avoidance tendencies in depression and childhood trauma: No effect of noradrenergic stimulation

Comprehensive Psychoneuroendocrinology

卷:8

Christian Otte¹  Janna Smit²  Linn Kristina Kuehl³  Katja Wingenfeld³  Michael Kaczmarczyk³  Christian Eric Deuter³ 

[1] Berlin Institute of Health (BIH), Berlin, Germany;

[2] Corresponding author. Charité Universitätsmedizin Berlin

[3]  Campus Benjamin Franklin Hindenburgdamm 30 12203 Berlin, 12203 Berlin, Germany.;

[4] Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany;

关键词: Approach-avoidance;    Emotional processing;    Major depressive disorder;    Adverse childhood experience;    Yohimbine;    Locus coeruleus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Adverse childhood experiences (ACE) are a major risk factor for major depressive disorder (MDD) in later life. Both conditions are characterized by dysregulations in the noradrenergic system related which again could represent a mediating mechanism for deficits in affective processing and behavioral functioning. In this double-blind, placebo-controlled study we tested the hypothesis that ACE and MDD are characterized by aberrant approach-avoidance (AA) tendencies and that these are mitigated after noradrenergic stimulation with yohimbine. In a mixed-measures, fully crossed design, participants (N = 131, 73 women) with/without MDD and with/without ACE received a single-dose of yohimbine or placebo on different days, followed by an AA task. We found modulation of AA tendencies by the emotional valence of target images, yet there were no effects of group or treatment. From these results, we conclude that AA tendencies are not critically affected by MDD or ACE and that the noradrenergic system is not substantially involved in this behavior.

【 授权许可】

Unknown