Gene Set Analysis: Challenges, Opportunities, and Future Research

Frontiers in Genetics

卷:11

关键词: gene expression;    gene set analysis;    gene set enrichment;    gene set database;    sensitivity;    specificity;   

DOI  :  10.3389/fgene.2020.00654

来源: DOAJ

【 摘 要 】

Gene set analysis methods are widely used to provide insight into high-throughput gene expression data. There are many gene set analysis methods available. These methods rely on various assumptions and have different requirements, strengths and weaknesses. In this paper, we classify gene set analysis methods based on their components, describe the underlying requirements and assumptions for each class, and provide directions for future research in developing and evaluating gene set analysis methods.

【 授权许可】

Unknown