The effect of polyunsaturated fatty acids on cardiovascular risk factors and urinary mercury in workers employed at electrolytic production of chlorine

International Journal of Occupational Medicine and Environmental Health

卷:34

Maciej Cyran¹  Barbara Turczyn²  Beata Smyk²  Anna Skoczyńska²  Anna Wojakowska²  Marta Skoczyńska³ 

[1] Maria Sklodowska-Curie Medical Academy, Warsaw, Poland;

[2] Wroclaw Medical University, Wrocław, Poland(Department of Internal and Occupational Medicine and Hypertension);

[3] Wroclaw Medical University, Wrocław, Poland(Department of Rheumatology and Internal Diseases);

关键词: blood pressure;    heart rate;    hdl-c;    pufa;    mercury exposure;    urinary hg;   

DOI  :  10.13075/ijomeh.1896.01597

来源: DOAJ

【 摘 要 】

ObjectivesWhile inorganic mercury is being gradually withdrawn from industry, environmental exposure to mercury is recognized as one of the greatestpresent toxicological problems. The aim of this study was to evaluate the effect of polyunsaturated fatty acids (PUFAs) supplementation on selectedcardiovascular risk factors and the urinary mercury (Hg-U) concentration in workers occupationally exposed to mercury vapor.Material and MethodsOverall, 38 workers of an electrolyzer hall (Hg-U: 46.6±35.7 μg/g creatinine) and a control group of 60 employees not exposed to Hg (Hg-U: 4.3±15.5μg/g creatinine) were included in a clinical cross-over study. Clinical and laboratory tests were carried out 4 times: before and after a 3-month periodof PUFAs supplementation (1000 mg daily), then after a 3-month break, and then after another 3-month period of PUFAs supplementation.ResultsThe baseline heart rate (HR) and serum triglyceride levels were higher in the Hg-exposed workers than in the controls, whereas systolic blood pressure(SBP) and cholesterol (C) levels exceeded normal values in both groups. There was a positive correlation between high-density lipoprotein 3 cholesterol(HDL 3 -C) and Hg-U levels. The PUFAs use was associated with a decrease in both HR and SBP. After the first stage of supplementation, a decrease inthe Hg-U concentration was observed. In a multivariate logistic regression model, decreases in Hg-U were associated only with exposure to mercury;OR ΔHg= 0.562 (95% CI: 0.323–0.979), p < 0.042. After the second 3-month period of PUFAs supplementation, a significant association betweenHDL 3 -C and a Hg-U decrease was shown: OR HDL 3 = 1.222 (95% CI: 1.01–1.46), p < 0.033.ConclusionsIn the workers exposed to mercury vapor,PUFAs supplementation led to some beneficial effects on HR and SBP. The first stage of supplementation was associated with a decrease in Hg-U inwhich HDL 3metabolism probably plays an important role. Int J Occup Med Environ Health. 2021;34(4):551–64

【 授权许可】

Unknown