Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

Pharmaceutics

卷:13

Ana L. Gomes dos Santos¹  Essyrose Mathew²  Dimitrios A. Lamprou²  Giulia Pitzanti² 

[1] Pharmaceutical Sciences, R&D BioPharmaceuticals, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK;

[2] School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK;

关键词: hollow microneedles;    transdermal drug delivery;    3D printing;    additive manufacturing;    digital light processing;    emerging technologies;   

DOI  :  10.3390/pharmaceutics13111837

来源: DOAJ

【 摘 要 】

3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays.

【 授权许可】

Unknown