Cognitive Impairment in People with Epilepsy

Journal of Clinical Medicine

卷:11

Martin Rakusa¹  Karmen Vizjak¹  Ajda Novak¹ 

[1] Department of Neurologic Diseases, University Medical Centre Maribor, 2000 Maribor, Slovenia;

关键词: epilepsy;    cognitive impairment;    seizures;    anti-epileptic drugs;    memory deficits;    EEG;   

DOI  :  10.3390/jcm11010267

来源: DOAJ

【 摘 要 】

People with epilepsy frequently have cognitive impairment. The majority of cognitive problems is influenced by a variety of interlinked factors, including the early onset of epilepsy and the frequency, intensity and duration of seizures, along with the anti-epileptic drug treatment. With a systematic review, we investigate significant factors about the cognitive impairment in epilepsy. Most cognitive problems in adult people with epilepsy include memory, attention and executive function deficits. However, which cognitive area is mainly affected highly depends on the location of epileptic activity. Moreover, modifications in signalling pathways and neuronal networks have an essential role in both the pathophysiology of epilepsy and in the mechanism responsible for cognitive impairment. Additionally, studies have shown that the use of polytherapy in the treatment of epilepsy with anti-epileptic drugs (AEDs) heightens the risk for cognitive impairment. It can be challenging to distinguish the contribution of each factor, because they are often closely intertwined.

【 授权许可】

Unknown