Xanthine scaffold: scope and potential in drug development

Heliyon

卷:4

Nivedita Singh¹  Sanjukta Patra¹  M.S. Thakur²  Ashwinee Kumar Shreshtha³ 

[1] Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India;

[2] Fermentation Technology and Bioengineering Department, Central Food Technological Research Institute, Mysore, India;

[3] Kathmandu University, Nepal;

关键词: Pharmaceutical chemistry;    Natural product chemistry;   

DOI  :  

来源: DOAJ

【 摘 要 】

Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc. giving them popular recognition. These compounds are best known for their diverse pharmaceutical applications as cyclic nucleotide phosphodiesterase inhibition, antagonization of adenosine receptor, anti-inflammatory, anti-microbial, anti-oxidant and anti-tumor activities. These properties incentivize to use xanthine as scaffold to develop new derivatives. Chemical synthesis contributes greater diversity in xanthine based derivatisation. With highlighting the existing challenges in chemical synthesis, the present review focuses the probable solution to fill existing lacuna. The review summarizes the available knowledge of xanthine based drugs development along with exploring new xanthine led chemical synthesis path for bringing diversification in xanthine based research. The main objective of this review is to explore the immense potential of xanthine as scaffold in drug development.

【 授权许可】

Unknown