Are circulating microRNAs suitable for the early detection of malignant mesothelioma? Results from a nested case–control study

BMC Research Notes

卷:12

Swaantje Casjens¹  Katarzyna Burek¹  Martin Lehnert¹  Thomas Brüning¹  Dirk Taeger¹  Georg Johnen¹  Daniel Gilbert Weber¹  Alexander Brik¹  the MoMar study group¹  Beate Pesch¹ 

[1] Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA);

关键词: Biomarker;    Blood;    Cancer;    Liquid biopsies;    Mesothelioma;    MicroRNA;   

DOI  :  10.1186/s13104-019-4113-7

来源: DOAJ

【 摘 要 】

Abstract Objective Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, miR-126-3p, and miR-103a-3p were analyzed in a nested case–control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. Results Using prediagnostic plasma samples collected in median 8.9 months prior the clinical diagnosis miR-132-3p, miR-126-3p, and miR-103a-3p revealed 0% sensitivity on a defined specificity of 98%. Thus, the analyzed miRNAs failed to detect the cancer in prediagnostic samples, showing that they are not feasible for the early detection of malignant mesothelioma. However, the miRNAs might still serve as possible markers for prognosis and response to therapy, but this needs to be analyzed in appropriate studies.

【 授权许可】

Unknown