HLA-G molecules in autoimmune diseases and infections

Frontiers in Immunology

卷:5

Enrico eFainardi¹  Roberta eRizzo²  Silvia eBolzani²  Daria eBortolotti² 

[1] Azienda Ospedaliera-Universitaria, Arcispedale S. Anna;

[2] University of Ferrara;

关键词: Autoimmunity;    Infection;    Inflammation;    regulation;    HLA-G;   

DOI  :  10.3389/fimmu.2014.00592

来源: DOAJ

【 摘 要 】

Human leukocyte antigen (HLA)-G molecule, a non-classical HLA-Ib molecule, is less polymorphic when compared to classical HLA class I molecules. HLA-G was first detected on cytotrophoblast cells at the feto-maternal interface but its expression is prevalent during viral infections and several autoimmune diseases. . HLA-G gene is characterized by polymorphisms at the 3' untranslated region and 5’ upstream regulatory region that regulate its expression and are associated with autoimmune diseases and viral infection susceptibility, creatingan unbalanced and pathologic environment. This review focuses on the role of HLA-G expression in autoimmune conditions and viral infections.

【 授权许可】

Unknown