Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study

Arabian Journal of Chemistry

卷:13

Alane Beatriz Vermelho¹  Christian Campos²  Alexandre Soares Rosado³  Leonardo da Cunha Boldrini⁴  Maria Cristina Pinheiro Pereira Reis Mansur⁴  Luciene Balottin⁴  Jonas Nobrega⁵  Elisabete Pereira dos Santos⁶  Claudia Lage⁷  Eduardo Ricci-Júnior⁷ 

[1]Correspondence author at: LADEG, Federal University of Rio de Janeiro, Brazil, Avenida Carlos Chagas Filho, 373, Centro de Ciências da Saúde – CCS, Cidade Universitária, Ilha do Fundão, CEP 21941-902, Brazil.

[2]|LADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Brazil

[3]|Postgraduate Program in Translational Biomedicine – BIOTRANS – Unigranrio, Inmetro, Uezo, Rio de Janeiro, Brazil

[4]|BIOINOVAR - Biocatalysis, Bioproducts and Bioenergy, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Brazil

[5]|LADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Brazil

[6]|LaRBio – Radiations and Biology Laboratory, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Brazil

[7]|Labio/Dimav/Inmetro – Laboratory of Tissue Bioengineering/Directorate of Metrology Applied to Life Sciences/National Institute of Metrology, Quality and Technology, Duque de Caxias, Rio de Janeiro, Brazil

关键词: Photoprotection;    Nanoemulsions;    Microbial-carotenoids;    Buriti oil;    SPF;   

DOI  :  

来源: DOAJ

【 摘 要 】

Photoprotective nanoemulsions are able to attenuate skin damage from overexposure to the sun, thus avoiding the immediate effects caused by ultraviolet radiation. The global cosmetics market understands that there is a demand and greater acceptance by consumers for formulations containing natural products compatible with the skin. Consequently, there is an increasingly need to develop such products that are safe and effective. Furthermore, there is a growing interest in nanoemulsions (NE) in the pharmaceutical industry, due the versatility of incorporating lipophilic substances into cosmetic formulations. In the present work, oil-in-water photoprotective nanoemulsions containing microbial carotenoids, buriti oil and chemical filters were developed and characterized. The essential physical properties of the droplets, the transmission electronic microscopy (TEM), the sun protection factor (SPF) as well as the stability of the formulations were determined. In vitro phototoxicity was evaluated using Balb 3 T3 with relative cell viability estimated by Neutral Red Uptake, with the Photo Irritation Factor (PIF) and the Medium Photo Effect Factor (MPF) as the measurement parameters. Nanoemulsion 3 (NE3) showed spherical morphology with an average droplet size of 142.11 ± 0.92 nm and polydispersity index (PDI) of 0.198 ± 0.017. This nanoemulsion containing microbial carotenoids and buriti oil exhibited a SPF of 36 ± 1.5. Neutral Red Uptake revealed that the cells kept their viability even after irradiation and those nanoemulsions containing the microbial carotenoids and buriti oil were not phototoxic. The addition of microbial carotenoids and buriti oil in nanoemulsions was positive in increasing the mean SPF values compared to the control formulation.

【 授权许可】

Unknown