Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice

Food and Agricultural Immunology

卷:29

Yiou Pan¹  Li Wang¹  Xi Chen¹  Ge Song¹  Hang Zhou¹  Aike Li¹  Weiwei Wang¹  Jianxue Liu² 

[1] Academy of State Administration of Grain;

[2] Henan University of Science and Technology;

关键词: ferulic acid;    high-fat diet;    metabolic syndrome;    mice;    obesity;   

DOI  :  10.1080/09540105.2018.1516739

来源: DOAJ

【 摘 要 】

This study aimed to determine whether mice fed ferulic acid (FA) would alleviate high-fat diet-induced obesity and obesity-related metabolic syndromes. Mice were divided into the following four groups and fed for 6 wk (n = 8): control diet (NC), high-fat diet (HF; 60% energy from fat), NC and HF supplemented with 0.5% (w/w) FA respectively. Mice fed HF-FA diet consumed same amount of energy, but had lower daily weight gain, white adipose tissue weight, body fat accumulation, blood glucose and had suppressed hepatic lipid accumulation and inflammatory cytokines (IL-6 and TNF-α) release (P < 0.05), compared with those in HF-fed mice. In conclusion, our findings indicate that dietary FA supplementation suppress body weight gain, body and hepatic fat accumulation, blood glucose elevation and inflammation in high fat diet-induced obese mice, suggesting that FA could be effective in lowering the risk of high fat-diet induced obesity and obesity-related metabolic syndromes.

【 授权许可】

Unknown