Frontiers in Aging Neuroscience | 卷:9 |
Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults | |
Clare E. Mackay1  Archana Singh-Manoux1  Mika Kivimäki1  Abda Mahmood2  Enikő Zsoldos2  Klaus P. Ebmeier2  Claire E. Sexton3  Heidi Johansen-Berg3  Naiara Demnitz3  Helen Dawes4  | |
[1] Department of Epidemiology and Public Health, University College LondonLondon, United Kingdom; | |
[2] Department of Psychiatry, University of Oxford, Warneford HospitalOxford, United Kingdom; | |
[3] Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of OxfordJohn Radcliffe Hospital, Oxford, United Kingdom; | |
[4] Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes UniversityOxford, United Kingdom; | |
关键词: mobility; gait; balance; aging; cognition; MRI; | |
DOI : 10.3389/fnagi.2017.00155 | |
来源: DOAJ |
【 摘 要 】
Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007–2009, using gait, balance and chair-stands tests. In 2012–2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.
【 授权许可】
Unknown