Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults

Frontiers in Aging Neuroscience

卷:9

Clare E. Mackay¹  Archana Singh-Manoux¹  Mika Kivimäki¹  Abda Mahmood²  Enikő Zsoldos²  Klaus P. Ebmeier²  Claire E. Sexton³  Heidi Johansen-Berg³  Naiara Demnitz³  Helen Dawes⁴ 

[1] Department of Epidemiology and Public Health, University College LondonLondon, United Kingdom;

[2] Department of Psychiatry, University of Oxford, Warneford HospitalOxford, United Kingdom;

[3] Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of OxfordJohn Radcliffe Hospital, Oxford, United Kingdom;

[4] Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes UniversityOxford, United Kingdom;

关键词: mobility;    gait;    balance;    aging;    cognition;    MRI;   

DOI  :  10.3389/fnagi.2017.00155

来源: DOAJ

【 摘 要 】

Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007–2009, using gait, balance and chair-stands tests. In 2012–2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.

【 授权许可】

Unknown