Cefiderocol for compassionate use in the treatment of complicated infections caused by extensively and pan-resistant Acinetobacter baumannii

Journal of Global Antimicrobial Resistance

卷:23

Giancarlo Ceccarelli¹  Alessandra Oliva²  Federica Sacco³  Massimiliano De Angelis³  Claudio M Mastroianni³  Maria Claudia Miele³  Mario Venditti³ 

[1]Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy

[2]|Corresponding author at: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Italy.

[3]|Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy

关键词: Cefiderocol;    Extensively and pan-resistant acinetobacter baumannii;    Serum bactericidal activity;    Spondylodiscitis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: This study presents real-life experience with cefiderocol used on a compassionate basis for treatment of three patients with severe infections caused by extensively/pan-drug resistant (XDR/PDR) Acinetobacter baumannii (Ab). Methods: Serum bactericidal activity was determined and considered as a surrogate of cefiderocol susceptibility. Results: Clinical improvement and microbiological eradication of A. baumannii were observed in all three patients, who were affected by extremely complex conditions either for type of infection, adverse effect or resistance profile of A. baumannii. Conclusion: Cefiderocol for XDR/PDR-Ab infections might be reconsidered, especially in light of the recent disappointing results of the CREDIBLE-CR study.

【 授权许可】

Unknown