Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea

Journal of Veterinary Internal Medicine

卷:36

Bianca D. Ballhausen¹  Melanie Werner²  Stefan Unterer²  Yury Zablotski²  Kathrin Busch²  Elisabeth Skotnitzki²  Felix Neuerer³  Jan S. Suchodolski⁴ 

[1] AniCura Clinic of Small Animal Medicine Haar Haar Germany;

[2] Clinic of Small Animal Internal Medicine Centre for Clinical Veterinary Medicine, Ludwig‐Maximilians‐University Munich Germany;

[3] Clinic of Small Animal Medicine Ismaning Ismaning Germany;

[4] Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Texas A&M University College Station Texas USA;

关键词: AHDS;    canine;    enteropathy;    HGE;    IBD;    intestinal;   

DOI  :  10.1111/jvim.16312

来源: DOAJ

【 摘 要 】

Abstract Background Acute enteropathy is a trigger of chronic gastrointestinal (GI) disease in humans. Objective To report the prevalence of and explore possible risk factors for signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD). Animals One hundred and fifty‐one dogs, 80 dogs with a historical diagnosis of AHD, 71 control dogs with no history of AHD. Methods In this retrospective longitudinal study, data were collected from dogs with a historical diagnosis of AHD and healthy controls matched by breed, age and sex, aged between 1 year and 15 years of age, for which a follow‐up of at least 12 months after enrolment was available. Dog owners responded to a questionnaire to determine the history of signs of chronic GI disease. Results There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P = .03; odds ratio = 2.57; confidence interval [CI] 95% 1.12‐6.31) over a similar observation time (median 4 years; range, 1‐12 years). Conclusions and Clinical Importance Severe intestinal mucosal damage and associated barrier dysfunction might trigger chronic GI disease later in life.

【 授权许可】

Unknown