Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria

The Pan African Medical Journal

卷:34

Vincent Oluseye Osunkalu¹  Oluwaseun Olabisi Adelekan²  Mulikat Adesola Badiru²  Kamal Ayobami Ismail³  Akinsegun Abduljaleel Akinbami³  Ebele Ifeyinwa Uche³  Adedoyin Owolabi Dosunmu³  Omolara Risqat Kamson⁴  Taiwo Modupe Balogun⁴ 

[1] Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idiaraba, Lagos, Nigeria;

[2] Department of Haematology and Blood Transfusion, General Hospital Marina, Lagos, Nigeria;

[3] Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Lagos, Nigeria;

[4] Department of Haematology and Blood Transfusion, Lagos State University Teaching Hospital, Lagos, Nigeria;

关键词: sickle cell anaemia;    methylene tetrahydrofolate reductase gene mutation;    c677t;    a1298c;   

DOI  :  10.11604/pamj.2019.34.213.19524

来源: DOAJ

【 摘 要 】

INTRODUCTION: The significant causes of mortality among individuals with sickle cell anaemia (SCA) such as acute chest syndrome and cerebrovascular disease are related to vascular occlusion. Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene in persons with sickle cell anaemia have been suggested as a potential risk for vaso-occlusive events, with the C677T and A1298C polymorphisms being the commonest. This study therefore aimed to establish the pattern of MTHFR C677T and A1298C gene mutations among adults with HbSS phenotype attending the Haematology Clinic in Lagos State University Teaching Hospital Lagos, Nigeria.

【 授权许可】

Unknown