Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters

Materials

卷:14

Gutemberg Alves¹  Carlos Fernando de Almeida Barros Mourão¹  Andrea Pintor²  Marcela Magno²  Isleine Caldas³  Pantaleo Scelza³  Fernanda Nunes³  Emanuele Di Edoardo⁴  Pietro Montemezzi⁵  Miriam Zaccaro Scelza⁶  Emanuelle Stellet Lourenço⁷  Fabiano Gonçalves⁷  Sandro Tavares⁷ 

[1] Clinical Research Unit of the Antonio Pedro Hospital, Universidade Federal Fluminense, Niterói 24033-900, RJ, Brazil;

[2] Department of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil;

[3] Geriatric Dentistry Department, Universidade Federal Fluminense, Niterói 24020-140, RJ, Brazil;

[4] Independent Researcher, 20100 Milan, Italy;

[5] Independent Researcher, 24128 Bergamo, Italy;

[6] Laboratory of Experimental Culture Cell (LECCel), Department of Endodontics, Faculty of Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, Brazil;

[7] Post-Graduate Program in Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, Brazil;

关键词: dentition;    permanent;    meta-analysis;    regenerative endodontics;    systematic review;   

DOI  :  10.3390/ma14164418

来源: DOAJ

【 摘 要 】

This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I² = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I² = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I² = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I² = 51%) and cold tests (0.70 (0.54, 0.84) I² = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests.

【 授权许可】

Unknown