Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Frontiers in Endocrinology

卷:9

Daniel J. Macqueen¹  Daniel Garcia de la Serrana² 

[1] School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom;

[2] School of Biology, Scottish Oceans Institute, University of St Andrews, St Andrews, United Kingdom;

关键词: insulin-like growth factor binding protein;    teleost fish;    genome duplication;    physiology;    comparative biology;    gene family evolution;   

DOI  :  10.3389/fendo.2018.00080

来源: DOAJ

【 摘 要 】

The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation—with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.

【 授权许可】

Unknown