Current Status of Anti-Drug Antibody Analysis Using Immunocapture-Liquid Chromatography/Mass Spectrometry

Journal of Applied Bioanalysis

卷:4

关键词: anti-drug antibody (ADA);    ADA isotyping;    immunocapture;    LBA;    LC/MS.;   

DOI  :  10.17145/jab.18.011

来源: DOAJ

【 摘 要 】

During drug development, anti-drug antibodies (ADA) is closely monitored for immunogenicity assessment. Ligand binding assay is currently the most widely used platform for ADA detection. Very recently, immunocapture-LC/MS was developed for ADA analysis including isotyping and semi-quantitation. This mini-review summarizes literatures pertaining to immunocapture-LC/MS ADA analysis with focus on methodology, applications and regulatory aspects. Current thinking and considerations as well as outlook are also presented.

【 授权许可】

Unknown