Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance

Bioactive Materials

卷:5

Fabrício Mezzomo Collares¹  Maria Eduarda Rodrigues Gama²  Isadora Martini Garcia²  Stéfani Becker Rodrigues²  Vicente Castelo Branco Leitune²  Mary Anne Melo³ 

[1] Operative Dentistry Division, General Dentistry Department University of Maryland School of Dentistry, Baltimore, MD, 21201, USA;

[2] Dental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil;

[3] Ph.D. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD, 21201, USA;

关键词: Dental materials;    Guanidine;    Antifungal agents;    Candidiasis;    Denture liner;   

DOI  :  

来源: DOAJ

【 摘 要 】

To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, Candida albicans. The solutions formulated with concentrations ranging from 0.125 to 0.50 wt% enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens. After 10 min-contact, the solution at lower concentration has reached total fungal elimination. The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration. The PHMGH aqueous solutions at 0.125 wt% could be applied to promote interim denture liner disinfection without promoting the loss of materials’ mechanical property.

【 授权许可】

Unknown