COL1A1 GENE SP1 POLYMORPHISM AND OSTEOPOROSIS RISK IN POSTMENOPAUSAL WOMEN

Кубанский научный медицинский вестник

卷:1

E. A. MAYLYAN¹ 

[1] Donetsk National Medical University named after M. Gorky;

关键词: col1a1 gene;    sp1 polymorphism;    women;    postmenopause;    osteoporosis;   

DOI  :  10.25207/1608-6228-2017-1-90-94

来源: DOAJ

【 摘 要 】

483 postmenopausal women took part in survey. It was established that GG genotype and G allele of COL1A1 gene 1546 (6252) G>T [Sp1 S>s] polymorphism provide protective effect for osteoporotic changes development at L1-L4 lumbar vertebrae, forearm distal department, left and right femurs proximal departments, including femoral neck. GT genotype and T allele of above-stated polymorphism are postmenopausal osteoporosis predictors in various sites of skeleton. The obtained data can be used for detection of predisposition to osteoporosis development at postmenopausal women and treatment-and-prophylactic actions efficiency rising.

【 授权许可】

Unknown