Influence of Magnetic Nanoparticles on the Focused Ultrasound Hyperthermia

Materials

卷:11

Katarzyna Kaczmarek¹  Tomasz Hornowski¹  Arkadiusz Józefczak¹  Bernadeta Dobosz² 

[1] Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61–614 Poznań, Poland;

[2] Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61–614 Poznań, Poland;

关键词: focused ultrasound;    therapeutic ultrasound;    ultrasound hyperthermia;    magnetic nanoparticles;    sonosensitizers;   

DOI  :  10.3390/ma11091607

来源: DOAJ

【 摘 要 】

Ultrasound hyperthermia is a medical treatment used to increase temperature of tissues. It can be used independently or as a supportive method for an anticancer treatment. The therapeutic efficacy of focused ultrasound hyperthermia can be improved using sonosensitizers, nanoparticles enhancing the attenuation and dissipation of acoustic energy. As sonosensitizers, we propose magnetic nanoparticles owing to their biodegradability, biocompatibility, and simple positioning in tissues using a magnetic field. Focused ultrasound hyperthermia studies were performed using tissue-mimicking phantoms. Temperature changes were measured at various ultrasound powers and distances from the center of the ultrasound focus. Specific absorption rate (SAR) values, describing the power deposition in the tissues during the hyperthermia treatment, were evaluated for the center of the focus point and for various distances from it. The results show that the addition of nanoparticles increases the SAR almost two times compared to that for the pure phantom. The highest SAR is obtained in the ultrasound focus; it decreases with the increase of the distance from the focus.

【 授权许可】

Unknown