The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Cancers

卷:13

Roby Zomer¹  Terrence J. Piva²  Nazim Nassar²  Srinivasareddy Telukutla³  Kanika Singh³  Ava Bachari³  Nitin Mantri³  Ellen Schanknecht³ 

[1] MGC Pharmaceuticals Limited, West Perth, WA 6005, Australia;

[2] School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia;

[3] The Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia;

关键词: prostate cancer;    cannabis;    cannabinoids;    cannabinoid receptors;    cancer;   

DOI  :  10.3390/cancers13164107

来源: DOAJ

【 摘 要 】

Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.

【 授权许可】

Unknown