Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis

Frontiers in Neuroscience

卷:16

Dong Feng Chen¹  Xinghuai Sun³  Kin-Sang Cho⁴  Yizhen Tang⁴  Simran Shah⁴ 

[1] ENT Hospital, Fudan University, Shanghai, China;

[2] Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China;

[3] Department of Ophthalmology, Eye Institute, Eye &

[4] Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States;

关键词: metabolomics;    metabolite profile;    glaucoma;    retinal ganglion cells;    optic neuropathy;   

DOI  :  10.3389/fnins.2022.835736

来源: DOAJ

【 摘 要 】

Glaucoma is a leading cause of blindness worldwide. It is suggested that primary open angle glaucoma (POAG), the most common form of glaucoma, may be associated with significant metabolic alternations, but the systemic literature review and meta-analysis in the area have been missing. Altered metabolomic profiles in the aqueous humor and plasma may serve as possible biomarkers for early detection or treatment targets. In this article, we performed a systematic meta-analysis of the current literature surrounding the metabolomics of patients with POAG and metabolites associated with the disease. Results suggest several metabolites found to be specifically altered in patients with POAG, suggesting broad generalizability and pathways for future research.

【 授权许可】

Unknown