Re-irradiation in lung disease by SBRT: a retrospective, single institutional study

Radiation Oncology

卷:13

Donatella Caivano¹  Maurizio Valeriani²  Sara De Matteis²  Mattia Falchetto Osti²  Paolo Bonome²  Vitaliana De Sanctis²  Giuseppe Minniti³  Ivana Russo⁴ 

[1] Departement of Radiation Oncology, CNAO (National Centre of Oncological Hadrontherapy);

[2] Department of Radiation Oncology, Faculty of “Medicina e Psicologia”, University of Rome “Sapienza”, Sant’Andrea Hospital;

[3] Neuromed - Mediterranean Neurological Institute;

[4] UPMC San Pietro FBF, Centro di Radioterapia ad alta specializzazione;

关键词: Re-irradiation;    SBRT;    Lung;    Primary or metastatic disease;   

DOI  :  10.1186/s13014-018-1041-y

来源: DOAJ

【 摘 要 】

Abstract Background The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48–151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40–126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40–120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5–100 Gy). The median time between the first and the second treatment was 18 months. Results Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3. Conclusions Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.

【 授权许可】

Unknown