Mixed Photon and Carbon-Ion Beam Radiotherapy in the Management of Non-Metastatic Nasopharyngeal Carcinoma

Frontiers in Oncology

卷:11

Lin Kong¹  Jiade J. Lu⁴  Jing Yang⁴  Jing Gao⁴  Xianxin Qiu⁴  Wenna Zhang⁴  Xiyin Guan⁴  Qingting Huang⁴  Weixu Hu⁴  Jiyi Hu⁴ 

[1] Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China;

[2] Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China;

[3] Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China;

[4] Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China;

关键词: nasopharyngeal carcinoma;    intensity modulated radiation therapy;    carbon ion radiation therapy (CIRT);    survival;    disease control;    toxicity;   

DOI  :  10.3389/fonc.2021.653050

来源: DOAJ

【 摘 要 】

BackgroundCarbon-ion radiotherapy (CIRT) may further increase the therapeutic ratio for patients with newly diagnosed nasopharyngeal carcinoma (NPC). The purpose of the current study is to examine the effectiveness and toxicity profile of photon-based intensity-modulated radiotherapy (IMRT) plus CIRT boost in a relatively large cohort of NPC patients.MethodsIn the current study, non-metastatic NPC patients treated with IMRT plus CIRT boost at Shanghai Proton and Heavy Ion Center between June, 2015 and June, 2018 were included. Overall survival (OS), progression-free survival (PFS), local control, regional control, and distant control were calculated with Kaplan–Meier method. Acute and late toxicities were graded using CTCAE 4.03.ResultsA total of 69 patients were included in the analysis. Among those, 74% of the patients had locoregionally advanced (stage III/IV) disease, and 92.8% had cervical lymphadenopathy. With a median follow-up of 31.9 months, the 3-year OS, PFS, local control, regional control, and distant control rates were 94.9, 85.2, 96.9, 98.4, and 89.7%, respectively. Mixed treatment of IMRT with CIRT boost was well tolerated. Severe acute toxicities induced by radiation therapy were observed in only two patients (dermatitis). No severe radiation-induced late toxicity was observed at the time of analysis. Univariable analysis showed N2/3 disease was correlated with an inferior distant control (p = 0.040).ConclusionMixed treatment of IMRT plus CIRT boost provides an excellent disease control and a favorable toxicity profile for patients with non-metastatic NPC. Further follow-up is necessary to evaluate the long-term survivals and toxicities more accurately.

【 授权许可】

Unknown