Poly(lactic acid)-Based Electrospun Fibrous Structures for Biomedical Applications

Applied Sciences

卷:12

Homa Maleki¹  Serena Danti²  Bahareh Azimi²  Saeed Ismaeilimoghadam³ 

[1] Department of Carpet, University of Birjand, Birjand 9717434765, Iran;

[2] Department of Civil and Industrial Engineering, University of Pisa, 56126 Pisa, Italy;

[3] Pisa Research Unit (UdR), Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Florence, Italy;

关键词: electrospinning;    fiber morphology;    scaffold;    PLA stereocomplex;    wound healing;    tissue engineering;   

DOI  :  10.3390/app12063192

来源: DOAJ

【 摘 要 】

Poly(lactic acid)(PLA) is an aliphatic polyester that can be derived from natural and renewable resources. Owing to favorable features, such as biocompatibility, biodegradability, good thermal and mechanical performance, and processability, PLA has been considered as one of the most promising biopolymers for biomedical applications. Particularly, electrospun PLA nanofibers with distinguishing characteristics, such as similarity to the extracellular matrix, large specific surface area and high porosity with small pore size and tunable mechanical properties for diverse applications, have recently given rise to advanced spillovers in the medical area. A variety of PLA-based nanofibrous structures have been explored for biomedical purposes, such as wound dressing, drug delivery systems, and tissue engineering scaffolds. This review highlights the recent advances in electrospinning of PLA-based structures for biomedical applications. It also gives a comprehensive discussion about the promising approaches suggested for optimizing the electrospun PLA nanofibrous structures towards the design of specific medical devices with appropriate physical, mechanical and biological functions.

【 授权许可】

Unknown