Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases

Pharmaceuticals

卷:15

Ali Alshehhi¹  Abdallah Mohammad Ibrahim²  Noora Alhajri³  Faheem Hyder Pottoo⁴  Rida Alsinan⁴  Muruj Alshehri⁴  Ali Alammar⁴  Mahdi Aleid⁴  Supriya Mishra⁵ 

[1] College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates;

[2] Department of Fundamentals of Nursing, College of Nursing, Imam Abdul Rahman Bin Faisal University, Dammam 31441, Saudi Arabia;

[3] Department of Medicine, Sheikh Shakhbout Medical City (SSMC), Abu Dhabi P.O. Box 127788, United Arab Emirates;

[4] Department of Pharmacology, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, Dammam 31441, Saudi Arabia;

[5] SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Delhi-NCR Campus, Modinagar, Ghaziabad 201204, UP, India;

关键词: thymoquinone;    anti-inflammation;    Alzheimer’s disease;    neuroinflammation;    Parkinson’s disease;    epilepsy;   

DOI  :  10.3390/ph15040408

来源: DOAJ

【 摘 要 】

Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those with memory and cognitive impairment. TQ protects brain cells from oxidative stress, which is especially pronounced in memory-related regions. TQ exhibits antineurotoxin characteristics, implying its role in preventing neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. TQ’s antioxidant and anti-inflammatory properties protect brain cells from damage and inflammation. Glutamate can trigger cell death by causing mitochondrial malfunction and the formation of reactive oxygen species (ROS). Reduction in ROS production can explain TQ effects in neuroinflammation. TQ can help prevent glutamate-induced apoptosis by suppressing mitochondrial malfunction. Several studies have demonstrated TQ’s role in inhibiting Toll-like receptors (TLRs) and some inflammatory mediators, leading to reduced inflammation and neurotoxicity. Several studies did not show any signs of dopaminergic neuron loss after TQ treatment in various animals. TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh). As a result, fresh memories are programmed to preserve the effects. Treatment with TQ has been linked to better outcomes and decreased side effects than other drugs.

【 授权许可】

Unknown