LincRNA-p21: Implications in Human Diseases

International Journal of Molecular Sciences

卷:16

Sai-Sai Tang¹  Xing-Dong Xiong¹  Bi-Ying Zheng² 

[1] Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China;

[2] Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China;

关键词: long non-coding RNA;    lincRNA-p21;    gene regulation;    diseases;   

DOI  :  10.3390/ijms160818732

来源: DOAJ

【 摘 要 】

Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases.

【 授权许可】

Unknown