CAPS and Munc13: CATCHRs that SNARE vesicles

Frontiers in Endocrinology

卷:4

Declan J James¹  Thomas F J Martin¹ 

[1] University of Wisconsin;

关键词: Vesicle fusion;    SNAREs;    Munc13;    Keywords: CAPS (aka CADPS);    priming factors;    vesicle priming;   

DOI  :  10.3389/fendo.2013.00187

来源: DOAJ

【 摘 要 】

Abstract. CAPS (Calcium-dependent Activator Protein for Secretion, aka CADPS) and Munc13 (Mammalian Unc-13) proteins function to prime vesicles for Ca2+-triggered exocytosis in neurons and neuroendocrine cells. CAPS and Munc13 proteins contain conserved C-terminal domains that promote the assembly of SNARE complexes for vesicle priming. Similarities of the C-terminal domains of CAPS/Munc13 proteins with CATCHR (Complex Associated with Tethering Containing Helical Rods) domains in multi-subunit tethering complexes have been reported. Multi-subunit tethering complexes coordinate multiple interactions for SNARE complex assembly at constitutive membrane fusion steps. We review aspects of these diverse tethering and priming factors to identify common operating principles.

【 授权许可】

Unknown